Dr Elena Lugli

Dr Elena Lugli

Research Assistant

Department: Core Research Laboratories
Division: Molecular Biology Laboratories

Qualifications

    Degrees

  • DPhil, University of Oxford, Oxford

Employment history

    Academic

  • Research Assistant, Natural History Museum, Molecular Labs, United Kingdom, 2015 - ongoing
  • Postdoctoral Research Associate, Kennedy Institute of Rheumatology, University of Oxford, United Kingdom, 2010 - 2015
  • Postdoctoral Research Associate, New York University Langone Medical Center, United States, 2000 - 2004

Publications

Lugli EB, Correia R, Fischer R, Lundberg K, Bracke KR, Montgomery AB, Kessler BM, Brusselle GG, Venables PJ (2015) Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis. Arthritis Research & Therapy, 17 (1) : 9 - 9. doi: 10.1186/s13075-015-0520-x

Quirke A-M, Lugli EB, Wegner N, Hamilton BC, Charles P, Chowdhury M, Ytterberg AJ, Zubarev RA, Potempa J, Culshaw S, Guo Y, Fisher BA, Thiele G, Mikuls TR, Venables PJW (2014) Heightened immune response to autocitrullinatedPorphyromonas gingivalispeptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis. Annals of the Rheumatic Diseases, 73 (1) : 263 - 269. doi: 10.1136/annrheumdis-2012-202726

Alzabin S, Quirke A-M, Lugli EB, Choudhury M, Charles PJ, Williams RO, Venables P (2013) Porphyromonas Gingivalis peptidylarginine Deiminase Exacerbates Collagen-Induced Arthritis In C57BL/6 mice. ARTHRITIS AND RHEUMATISM 65 : S950 - S950.

Lugli EB, Venables P, Correia R, Lundberg K, Bracke K, Brusselle G (2013) Influence Of Smoking On Citrullinated Proteins and Porphyromonas Gingivalis In The Lung: A Priming Site For Autoimmunity In RA. ARTHRITIS AND RHEUMATISM 65 : S344 - S345.

Lugli EB, Montgomery A, Lundberg K, Bracke K, Brusselle G, Venables PJ (2013) A1.3 Citrullination in Healthy and Inflamed Lung Tissue as a Priming Site for Autoimmunity in RA. Annals of the Rheumatic Diseases 72 (Suppl 1) : BMJ : A1.3 - A2. doi: 10.1136/annrheumdis-2013-203214.3

Lugli EB, Chowdhury M, Charles PJ, Crooks MG, Hart SP, Venables PJ, Fisher BA (2012) Anti-Cyclic Citrullinated Peptide Antibodies in Idiopathic Pulmonary Fibrosis Are Not Citrulline-Specific: Implications for the Pathogenesis of Rheumatoid Arthritis.. ARTHRITIS AND RHEUMATISM 64 (10) : S513 - S513.

Quirke A-M, Wegner N, Hamilton B, Charles PJ, Chowdhury M, Lugli EB, Potempa J, Thiele GM, Mikuls TR, Venables P (2011) Heightened Immune Response to Autocitrullinated Porphyromonas Gingivalis Peptidylarginine Deiminase Is a Potential Mechanism for Breaching Immunologic Tolerance in Rheumatoid Arthritis.. ARTHRITIS AND RHEUMATISM 63 (10) : S987 - S987.

del Pilar Molina-Portela M, Lugli EB, Recio-Pinto E, Raper J (2005) Trypanosome lytic factor, a subclass of high-density lipoprotein, forms cation-selective pores in membranes. Molecular and Biochemical Parasitology, 144 (2) : 218 - 226. doi: 10.1016/j.molbiopara.2005.08.018

Lugli EB, Pouliot M, Portela MDPM, Loomis MR, Raper J (2004) Characterization of primate trypanosome lytic factors. Molecular and Biochemical Parasitology, 138 (1) : 9 - 20. doi: 10.1016/j.molbiopara.2004.07.004

Green HP, del Pilar Molina Portela M, St. Jean EN, Lugli EB, Raper J (2003) Evidence for a Trypanosoma brucei Lipoprotein Scavenger Receptor. Journal of Biological Chemistry, 278 (1) : 422 - 427. doi: 10.1074/jbc.m207215200

HERVÉ CA, LUGLI EB, BRAND A, GRIFFITHS DJ, VENABLES PJW (2002) Autoantibodies to human endogenous retrovirus-K are frequently detected in health and disease and react with multiple epitopes. Clinical and Experimental Immunology, 128 (1) : 75 - 82. doi: 10.1046/j.1365-2249.2002.01735.x

Raper J, Portela MPM, Redpath M, Tomlinson S, Lugli E, Green H (2002) Natural immunity to human African trypanosomiasis: trypanosome lytic factors and the blood incubation infectivity test. Transactions of the Royal Society of Tropical Medicine and Hygiene, 96 : S145 - S150. doi: 10.1016/s0035-9203(02)90067-2

Raper J (2001) Trypanosome lytic factors: novel mediators of human innate immunity. Current Opinion in Microbiology, 4 (4) : 402 - 408. doi: 10.1016/s1369-5274(00)00226-5

Brand A, Herve CA, Lugli EB, Griffiths DJ, Venables PJW (2001) Antibodies to immunodominant epitopes of human retrovirus-5 in SLE. RHEUMATOLOGY 40 : 14 - 14.

Herve CA, Lugli EB, Brand A, Griffiths DJ, Venables PJW (2001) Antibodies to HERV-K in rheumatic disease are antigen-driven. RHEUMATOLOGY 40 : 13 - 13.

Lugli EB, Bampton ETW, Ferguson DJP, Wakefield AE (1999) Cell surface protease PRT1 identified in the fungal pathogen Pneumocystis carinii. Molecular Microbiology, 31 (6) : 1723 - 1733. doi: 10.1046/j.1365-2958.1999.01306.x

Lugli EB, Allen AG, Wakefield AE (1997) A Pneumocystis carinii multi-gene family with homology to subtilisin-like serine proteases. Microbiology, 143 (7) : 2223 - 2236. doi: 10.1099/00221287-143-7-2223

BANERJI S, LUGLI EB, MILLER RF, WAKEFIELD AE (1995) Analysis of Genetic Diversity at the arom Locus in Isolates of Pneumocystis carinii. The Journal of Eukaryotic Microbiology, 42 (6) : 675 - 679. doi: 10.1111/j.1550-7408.1995.tb01614.x

BANERJI S, LUGLI EB, WAKEFIELD AE (1994) IDENTIFICATION OF 2 GENETICALLY DISTINCT STRAINS OF PNEUMOCYSTIS-CARINII IN INFECTED FERRET LUNGS. JOURNAL OF EUKARYOTIC MICROBIOLOGY, 41 (5) : S73 - S73.

Courses taught

MSc: Molecular systematics
12/2016.

Introduction

Qualifications

    Degrees

  • DPhil, University of Oxford, Oxford

Employment history

    Academic

  • Research Assistant, Natural History Museum, Molecular Labs, United Kingdom, 2015 - ongoing
  • Postdoctoral Research Associate, Kennedy Institute of Rheumatology, University of Oxford, United Kingdom, 2010 - 2015
  • Postdoctoral Research Associate, New York University Langone Medical Center, United States, 2000 - 2004
Publications

Publications

Lugli EB, Correia R, Fischer R, Lundberg K, Bracke KR, Montgomery AB, Kessler BM, Brusselle GG, Venables PJ (2015) Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis. Arthritis Research & Therapy, 17 (1) : 9 - 9. doi: 10.1186/s13075-015-0520-x

Quirke A-M, Lugli EB, Wegner N, Hamilton BC, Charles P, Chowdhury M, Ytterberg AJ, Zubarev RA, Potempa J, Culshaw S, Guo Y, Fisher BA, Thiele G, Mikuls TR, Venables PJW (2014) Heightened immune response to autocitrullinatedPorphyromonas gingivalispeptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis. Annals of the Rheumatic Diseases, 73 (1) : 263 - 269. doi: 10.1136/annrheumdis-2012-202726

Alzabin S, Quirke A-M, Lugli EB, Choudhury M, Charles PJ, Williams RO, Venables P (2013) Porphyromonas Gingivalis peptidylarginine Deiminase Exacerbates Collagen-Induced Arthritis In C57BL/6 mice. ARTHRITIS AND RHEUMATISM 65 : S950 - S950.

Lugli EB, Venables P, Correia R, Lundberg K, Bracke K, Brusselle G (2013) Influence Of Smoking On Citrullinated Proteins and Porphyromonas Gingivalis In The Lung: A Priming Site For Autoimmunity In RA. ARTHRITIS AND RHEUMATISM 65 : S344 - S345.

Lugli EB, Montgomery A, Lundberg K, Bracke K, Brusselle G, Venables PJ (2013) A1.3 Citrullination in Healthy and Inflamed Lung Tissue as a Priming Site for Autoimmunity in RA. Annals of the Rheumatic Diseases 72 (Suppl 1) : BMJ : A1.3 - A2. doi: 10.1136/annrheumdis-2013-203214.3

Lugli EB, Chowdhury M, Charles PJ, Crooks MG, Hart SP, Venables PJ, Fisher BA (2012) Anti-Cyclic Citrullinated Peptide Antibodies in Idiopathic Pulmonary Fibrosis Are Not Citrulline-Specific: Implications for the Pathogenesis of Rheumatoid Arthritis.. ARTHRITIS AND RHEUMATISM 64 (10) : S513 - S513.

Quirke A-M, Wegner N, Hamilton B, Charles PJ, Chowdhury M, Lugli EB, Potempa J, Thiele GM, Mikuls TR, Venables P (2011) Heightened Immune Response to Autocitrullinated Porphyromonas Gingivalis Peptidylarginine Deiminase Is a Potential Mechanism for Breaching Immunologic Tolerance in Rheumatoid Arthritis.. ARTHRITIS AND RHEUMATISM 63 (10) : S987 - S987.

del Pilar Molina-Portela M, Lugli EB, Recio-Pinto E, Raper J (2005) Trypanosome lytic factor, a subclass of high-density lipoprotein, forms cation-selective pores in membranes. Molecular and Biochemical Parasitology, 144 (2) : 218 - 226. doi: 10.1016/j.molbiopara.2005.08.018

Lugli EB, Pouliot M, Portela MDPM, Loomis MR, Raper J (2004) Characterization of primate trypanosome lytic factors. Molecular and Biochemical Parasitology, 138 (1) : 9 - 20. doi: 10.1016/j.molbiopara.2004.07.004

Green HP, del Pilar Molina Portela M, St. Jean EN, Lugli EB, Raper J (2003) Evidence for a Trypanosoma brucei Lipoprotein Scavenger Receptor. Journal of Biological Chemistry, 278 (1) : 422 - 427. doi: 10.1074/jbc.m207215200

HERVÉ CA, LUGLI EB, BRAND A, GRIFFITHS DJ, VENABLES PJW (2002) Autoantibodies to human endogenous retrovirus-K are frequently detected in health and disease and react with multiple epitopes. Clinical and Experimental Immunology, 128 (1) : 75 - 82. doi: 10.1046/j.1365-2249.2002.01735.x

Raper J, Portela MPM, Redpath M, Tomlinson S, Lugli E, Green H (2002) Natural immunity to human African trypanosomiasis: trypanosome lytic factors and the blood incubation infectivity test. Transactions of the Royal Society of Tropical Medicine and Hygiene, 96 : S145 - S150. doi: 10.1016/s0035-9203(02)90067-2

Raper J (2001) Trypanosome lytic factors: novel mediators of human innate immunity. Current Opinion in Microbiology, 4 (4) : 402 - 408. doi: 10.1016/s1369-5274(00)00226-5

Brand A, Herve CA, Lugli EB, Griffiths DJ, Venables PJW (2001) Antibodies to immunodominant epitopes of human retrovirus-5 in SLE. RHEUMATOLOGY 40 : 14 - 14.

Herve CA, Lugli EB, Brand A, Griffiths DJ, Venables PJW (2001) Antibodies to HERV-K in rheumatic disease are antigen-driven. RHEUMATOLOGY 40 : 13 - 13.

Lugli EB, Bampton ETW, Ferguson DJP, Wakefield AE (1999) Cell surface protease PRT1 identified in the fungal pathogen Pneumocystis carinii. Molecular Microbiology, 31 (6) : 1723 - 1733. doi: 10.1046/j.1365-2958.1999.01306.x

Lugli EB, Allen AG, Wakefield AE (1997) A Pneumocystis carinii multi-gene family with homology to subtilisin-like serine proteases. Microbiology, 143 (7) : 2223 - 2236. doi: 10.1099/00221287-143-7-2223

BANERJI S, LUGLI EB, MILLER RF, WAKEFIELD AE (1995) Analysis of Genetic Diversity at the arom Locus in Isolates of Pneumocystis carinii. The Journal of Eukaryotic Microbiology, 42 (6) : 675 - 679. doi: 10.1111/j.1550-7408.1995.tb01614.x

BANERJI S, LUGLI EB, WAKEFIELD AE (1994) IDENTIFICATION OF 2 GENETICALLY DISTINCT STRAINS OF PNEUMOCYSTIS-CARINII IN INFECTED FERRET LUNGS. JOURNAL OF EUKARYOTIC MICROBIOLOGY, 41 (5) : S73 - S73.

Teaching and students

Courses taught

MSc: Molecular systematics
12/2016.